THERAPEUTIC SIGNIFICANCE OF INDOLE SCAFFOLD IN MEDICINAL CHEMISTRYAbstract
Discovery of New Chemical Entities (NCEs) is the result of a series of high throughput screening process after the successful design and synthesis scheme. The indole nucleus is an important heterocyclic compound containing nitrogen, and it has been a source of vital therapeutic agents. It is noteworthy in recent advances of synthetic, medicinal chemistry; the last decade has been witnessed with a multitude of reports on several indole derivatives corroborating these chemical entities to be an eminent target for the discovery of new drugs. Global research investigations published has outstanding impact attention for the scientists working on indole derivatives which transformed into various commercially approved indole candidate in the commercial market and there are several in the pipeline. This review highlighted recent achievements of indole lead molecules in biological, chemical, and pharmacological activity having diverse perspectives on how this indole moiety as a privileged structure may be browbeaten for elucidating salubrious biological activities.
K. Hussain, M. J. Alam, A. Hussain and N. A. Siddique *
Bioactive Natural Compound, Laboratory (BNCL), Department of Pharmacognosy and Phytochemistry, Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh, India.
11 February 2020
27 April 2020
08 May 2020
01 November 2020