A CONCISE REVIEW ON SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM: A POTENTIAL TOOL TO INCREASE DRUG BIOAVAILABILITYAbstract
Oral route is the easiest and most convenient route for drug administration more than 40% of new chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug delivery. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs are composed of an oil phase, surfactant, and cosurfactant or cosolvent. SNEDDSs characteristics, their ability to dissolve a drug, and in-vivo considerations are determinant factors in the choice of SNEDDSs excipients. SNEDDS is a proven method for enhancing solubility and bioavailability of lipophilic compounds. Considering the ease of large-scale production and the robustness of SNEDDS, several formulations techniques are commercially available. The review provides exhaustive insight about the potential of SNEDDS in improving bioavailability of poorly soluble drugs.
Neha S. Gallani *, Kanchan Dhamai and S. J. Dighade
Institute of Pharmacy and Research, Badnera- Amravati, Maharashtra, India.
15 December 2022
08 July 2023
22 August 2023
01 September 2023