A CONVENIENT SYNTHESIS AND BIOCIDAL ACTIVITY OF (N-ALKYL/ARYL SULPHONAMIDO)-4H-BENZ [d] OXAZIN-2-ONE DERIVATIVESAbstract
Compounds with a 2(H)-1, 4-benzoxazin-3(4H)-one skeleton have attached the attention of phytochemistry researchers since 2, 4-dihydroxy-(2H)-1,4-benzoxazin-3(4H) and 2,4-dihydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one were isolated from plants belonging to the Poaceae family. These compounds exihibit interesting properties11 such as phytotoxic, antimicrobial12, antifeedent, antifungal and insecticidal properties. The reaction of CSI with 2-Chlorobenzyl alcohol result in N-chlorosulphonyl derivatives, which show antibacterial potency. Futher, N-chlorosulphonyl derivatives can be easily cyclofunctionalized. This cyclofunctionalization has been exploited in the synthesis of the title compounds (3). Thus, the title compound being oxygen analogues of 1, 3-thiazine derivatives together with N-sulphonamide moiety could be expected to exhibit enhanced bioactivities14-18.
Manoj Kumar Srivastava* and Anamika Pandey
Department of Chemistry, M.G. Post Graduate College, Gorakhpur-273001 (U.P.), India.
02 June 2014
12 August, 2014
16 November, 2014
01 January, 2015