A GREENER CHEMISTRY APPROACH FOR SYNTHESIS OF 4-(4-HYDROXYPHENYL)-6-METHYL-2-OXO-1,2,3,4 TETRAHYDROPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
AbstractThe objective of present research work is to provide green technique for synthesis of 4-(4-Hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester. Pyrimidine derivatives are well known in the pharmaceutical industry and exhibit to possess a broad spectrum of biological activities which makes their wider application as a key building block for pharmaceutical agents. Highly efficient and simple methods complying with principle of Green chemistry have been described in this manuscript for the synthesis with competent yields. As part of current studies, we here in report economical practical techniques like- microwave synthesis, mortal-pastel method (mechanochemistry) and by application of green solvents for the synthesis. On completion of reaction the products were characterized by Infra Red Spectroscopy, Nuclear Magnetic Resonance Spectroscopy and Mass Spectra. The specified methods for synthesis are more convenient and reactions can be carried out in higher yield (80-96%), shorter reaction time (3-30 min) and milder conditions, without generation of pollution and safer to analyst.
Article Information
63
5548-5555
523
1940
English
IJPSR
D. Jagwani* and P. Joshi
Medi-Caps Group of Institutions, Pigdamber, Rau, Indore- 453331, Madhya Pradesh, India
devaanshi.jagwani@gmail.com
04 May, 2014
16 July, 2014
28 August, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5548-55
01 December 2014
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