A NEW SERIES OF CHALCONES INCORPORATED WITH PYRIDINE MOIETY AS POTENTIAL ANTI-BACTERIAL AGENTSAbstract
A new series of chalcones have been designed and synthesized, which are incorporated with pyridine moiety chalcones possess heterocyclic rings like pyridine, pyrazole, indole, etc. These heterocycles are cyclic compounds in which one or more atoms of the ring are hetero atoms: O, N, S, P, etc. These are important components in many of the pharmaceuticals and therapeutic drugs. These are present in so many biologically relevant molecules like amino acids, nucleic acids and hormones. In my work, I have used a pyridine compound to synthesis the chalcones. Pyridine is a basic heterocyclic organic compound with chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH-) replaced by a nitrogen atom. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals and vitamins. Historically, pyridine was produced from coal tar. It has an unpleasant fish-like smell. Nowadays, pyridine is produced on a scale of about 20,000 tonnes per year worldwide. A reaction involving Claisen-Schmidt condensation of 1- (pyridin-2-yl) ethanone with different aryl aldehydes in the presence of base catalyst have been attempted in this work. The product chalcones and their derivatives were compared with standard drugs and were confirmed by FT- IR and 1H-NMR and were also subjected to anti-bacterial analysis.
D. Vimala, P. Subashini and S. S. Shafi *
Department of Chemistry, Thiruvalluvar University, Serkkadu, Vellore, Tamil Nadu, India.
23 August 2019
15 February 2020
09 March 2020
01 August 2020