A NOVEL OPHTHALMIC DRUG DELIVERY SYSTEM: IN-SITU GELAbstract
The ophthalmic in-situ gels now days proved an palpable sustained drug delivery in various eye diseases. The formulation of in-situ gels for eye which carries the advantages like easy for administration, reduces frequency of dose and improves patient compliance. The formation of in-situ gels depends on phase transition system or sol-gel transition system. The formulation approaches like temperature intonation, pH change and presence of ions from which the drug gets released in a sustained and controlled manner are utilised for in-situ gels. Various polymers that are used for the formulation of in-situ gels include chitosan, Pluronic F-127, poly-caprolactone, gellan gum, alginic acid, xyloglucan, pectin etc.
A.P. Patil*, A.A. Tagalpallewar, G.M. Rasve, A.V. Bendre, P.G. Khapekar
Sinhgad Institute of Pharmacy, Narhe, Pune - 411 041, Maharashtra, India
05 May, 2012
13 June, 2012
15 August, 2012
01 September, 2012