A PRELIMINARY INVESTIGATION OF TUMOR TAKE INHIBITORY ACTIVITY OF ETHANOLIC LEAF EXTRACT OF MURRAYA KOENIGII LINN. IN MICEAbstract
The present study was undertaken to explore the tumor take inhibitory effects of ethanolic extract of Murraya koenigii in rodents. Tumor take inhibitory activity was investigated in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract at dose of 50mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth of tumor after injection of B16F10 melanoma cells into the dorsal skin of mice. Pretreatment with the extract and showed delay tumor growth by increasing the volume doubling time, VDT (p<0.01), growth delay, GD (p< 0.01) and mean survival time, MST (p<0.001). Tumor regression studies showed a regression response for tumor growth in vivo of murine mouse melanoma tumor cell lines, demonstrated by increasing the VDT and GD
D. Iyer and U. K. Patil*
Division of Pharmacognosy and Natural Product Research, Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar, Madhya Pradesh, India.
08 July, 2013
20 October, 2013
17 November, 2013
01 December, 2013