A QUEST FOR BETTER PROBIOTIC DELIVERY AND FRONTIERS OF PROBIOTIC APPLICATION IN MEDICAL SCIENCE: A CRITICAL REVIEWAbstract
Probiotics are live microorganisms that when introduced orally positively contribute to the activity of the intestinal microflora and the health of its host. Various studies showed that probiotics are potentially able to contribute to treatments of many diseases. They may not cure any disease, but can significantly improve the patient’s condition and also can prevent many infections. Recent studies confirmed that gut microbiota has a direct connection to the behavior and development of the brain. This review is done in two parts. The first part discusses how micro-encapsulation can improve targeted delivery of probiotics where second part discusses the effects of probiotics on various diseases. On the first half of this review, we will see micro-encapsulation allows core ingredients or probiotics to be separated from the environment by a protective coating which can enhance shelf-life of probiotics. The objective of this review is to study the efficiency of different encapsulation materials and methods to understand and control the delivery of probiotic by the conventional method to improve drug uptake, release and absorption by making it resistant from the harsh environment (Gastric juice and bile salt). On the second half of this review, we will encounter how probiotics are an essential part of the gut-brain axis and gut-brain signaling, how they influence neural development and help in the treatment of various neurodegenerative diseases like Autism, Alzheimer’s disease, and Parkinson’s disease and how psychobiotics can improve mental health. Probiotics are very helpful in the treatment of various gastroenteritic disorders and also in cases of HIV and Cancer.
R. Chowdhury and T. Chakraborty *
Department of Life Science, Guru Nanak Institute of Pharmaceutical Science and Technology, Panihati, Kolkata, West Bengal, India.
19 January 2019
07 April 2019
20 April 2019
01 September 2019