A RANDOMIZED CLINICAL TRIAL TO ASSESS AND COMPARE THE ANTIMICROBIAL ACTIVITY OF PLANTS OF LYTHRACEAE FAMILY WITH HIORA MOUTH WASHES IN SUBJECTS WITH CHRONIC PERIODONTITIS – “UNVEILING THE UNSEEN EFFECTS”Abstract
Aims and objectives: Periodontal disease is the most common disease associated with microbial infection with destruction of supporting structures. The aim of the present study is compare the antimicrobial efficacy of plants of lythraceae family with hiora mouthwash in subjects with chronic periodontitis. Materials and methods: A total of 90 subjects were taken and randomly divided into three groups with 30 each. Group 1 received punica mouthwash, group 2 with lawsone mouth wash and group3 hiora mouth wash. Oral rinse technique was performed. Total microbial load and specific aerobic and anaerobic bacteria like Streptococci, staphylococci species, Agregatibacter actinomycetemcomitans, and Porphyromonas gingivalis were determined. Subjects were instructed to use given mouth washes twice daily with volume of 5ml/rinse for 30 sec and later post therapeutic samples were collected 1hr and 1week following drug usage and they were evaluated for total microbial load. Results: Statistical analysis was performed using chi square and one way ANOVA. All the three groups were compared at different time intervals which showed significant difference (P=0.000*) in the mean value of microbial load at 1 hr & 1 week time intervals. When multiple comparisons were done highly significant results were obtained (P=0.000*) revealing punica with superior antimicrobial activity when compared to lawsone and hiora mouth wash. Taste and olfactory satisfaction was superior with hiora mouth wash. Conclusion: The current research work revealed superior antimicrobial activity with punica when compared with lawsone and hiora at all time intervals.
S. Bhavana *, P. Nahar, C. R. Lakshmi, N. B. Kilaru and R. Vemugunta
Department of Oral Medicine and Radiology, Pacific Academy of Higher Education and Research University, Pacific hills, Udaipur, Rajasthan, India.
18 June, 2015
28 August, 2015
17 October, 2015
01 May, 2017