A RECENT SURVEY ON CHEMICAL AND BIOLOGICAL SIGNIFICANCE OF ISATIN DERIVATIVES
AbstractIsatin, a heterocyclic moiety, is a significant scaffold in medicinal chemistry. Isatin contains a nitrogen atom at position 1 and two ketone groups at positions 2 and 3. It consists of two cyclic rings, one of which is a six-membered ring, and the other is a five-membered ring. It is a resourceful nucleus for the synthesis of several pharmacologically active molecules. Isatin itself acquires an extensive range of biological activities. Currently, the design of unique isatin derivatives as potent drugs is the key role of the researchers. The focus of this present study is to overview the recent literature published on isatin derivatives. In this review, some of the pharmacological activities of isatin derivatives such as anticancer, antibacterial, antiviral, antifungal, antioxidant, antitubercular, anti-malarial, antidiabetic, anticonvulsant, analgesic, and anti-inflammatory activities were reported. From these studies, isatin has been established as the more promising candidate for further research and investigations in many fields.
Article Information
3
5161-5173
3631 KB
629
English
IJPSR
P. Sowmiya * and K. Girija
Department of Pharmaceutical Chemistry, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, India.
sowmi0696@gmail.com
04 August 2020
11 February 2021
24 May 2021
10.13040/IJPSR.0975-8232.12(10).5161-73
01 October 2021
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