A REVIEW OF THE MUTUALISTIC RELATIONSHIP OF ENDOPHYTIC FUNGI FOR THE PRODUCTION OF BIOACTIVE METABOLITESAbstract
Endophytes constitute a remarkably multifarious group of microorganisms ubiquitous in plants and maintain an imperceptible association with their hosts for at least a part of their life cycle. Their enormous biological diversity, coupled with their capability to biosynthesize bioactive secondary metabolites, has provided the impetus for a number of investigations on endophytes. There is a need to search new ecological niches for the potential of natural bioactive agents for different pharmaceutical, agriculture, and industrial application; these should be renewable, eco-friendly, and easily obtainable natural products discovery in the search for new drugs and is the most potent source for the discovery of novel bioactive compounds. Therefore, a large number of bioactive compounds are isolated from plants, bacteria, fungi, and many other organisms. Endophytic fungi, the most promising of these, have been a source of various such bioactive compounds. Many of these compounds are being used for the treatment of a number of diseases. This review emphasis on the biology of fungal endophytes, their discovery, isolation, identification by morphological and molecular methods, production, purification and structure elucidation of the bioactive compounds.
Mohd Azharuddin *, Mohammad Saad and Amol R. Kharat
Department of Pharmacognosy, Government College of Pharmacy, Aurangabad, Maharashtra, India.
09 September 2022
20 October 2022
18 November 2022
01 June 2023