A REVIEW ON ANTIMICROBIAL POTENTIAL OF SULFONAMIDE SCAFFOLD
AbstractSulfonamides, sometimes called sulfa drugs, are the first drug that is largely employed and systematically essential for preventive and chemotherapeutic agents against various bacteria. Sulfonamides possess a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti-epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, antiretroviral, non-peptidic vasopressin receptor antagonists, anti-cancer, anti-inflammatory, translation initiation inhibitors, and used as a diuretic. The rapid evolution of drug-resistant bacterial and fungal infections has demanded a universal effort to search for new generation sulfonamide derivatives. The sulphonamides or sulfa drugs competitively inhibit folic acid synthesis in microorganisms and subsequently inhibit the multiplication of bacteria but do not actively kill them. These sulfonamides have a variety of synthetic reactions to work with. On the basis of the literature survey, the present review highlights research work in the recent decade, including potential antimicrobial activities of sulfonamides compounds. This review covers current advances related to synthesis and pharmacological effects of sulfonamides, especially in apprehension to anti-microbial agents.
Article Information
2
2535-2547
869
1476
English
IJPSR
P. A. Petkar and J. R. Jagtap *
Department of Pharmaceutical Chemistry, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India.
jayarjagtap@rediffmail.com
25 April 2020
10 November 2020
12 April 2021
10.13040/IJPSR.0975-8232.12(5).2535-47
01 May 2021
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