A REVIEW ON BIOCHEMICAL AND THERAPEUTIC ASPECTS OF GLUTAMINASEAbstract
One of the prime candidates in the treatment of debilitating human cancers includes a family of enzymes referred to as L- glutaminases. The antitumor activity of these enzymes found effective in countering Acute Lymphoblastic Leukemia (ALL a commonly diagnosed pediatric cancer.). Further it is found to inhibit four human tumour cell lines namely Hep-G2 [Human hepatocellular carcinoma cell line], MCF-7 [Breast cancer cell line], HCT-116 [Colon cell line] and A549 [Human lung Carcinoma]. Apart from therapeutic use, it is having a number of other applications like in food industry, analysis and in production of fine chemicals. This review, hence, mainly focuses on the biochemical aspects of L-Glutaminase production, aiming to comprehend the physiochemical characteristics, application of L-Glutaminase and its properties. Processes central to these biochemical aspects, including submerged fermentation and Solid state fermentation of L- glutaminase producing organisms are also discussed.
R. Unissa *, M. Sudhakar, A. S. K. Reddy and K. N. Sravanthi
Malla Reddy College of Pharmacy, Maisammaguda, Dhulpally, Secunderabad, Hyderabad. India.
17 April 2014
28 June 2014
10 July 2014
01 November 2014