A REVIEW ON CHROMEN DERIVATIVES AS ANTIEPILEPTICSAbstract
Chromens are oxygen-containing heterocycles, abundantly found in nature in the form of flavone, is flavones, flavanones, catechins, anthocyanins and collectively known as flavonoids and isoflavonoids. Being a polar and ionizable aromatic compound, it improves the pharmacokinetic characteristics of lead molecules. Imidazole derivatives have occupied a unique place in the field of medicinal chemistry. Therefore, the incorporation of the chromen nucleus is an important synthetic strategy in drug discovery. The high therapeutic properties of the chromen related drugs have encouraged the researchers to synthesize new chemotherapeutic agents. A variety of cellular targets are interacting with the derivatives of chromen and that can be responsible for their wide-ranging epileptic activities. The substitution of chromen nucleus is a crucial step in the drug discovery process. In the present review, chromen derivatives having antiepileptic activity is described using a structural substitution pattern. The interest in chromen is ever-growing since they offer a fairly diverse chemical space for exploration of medicinal potential.
R. K. Kushwaha, K. Singh *, M. Prasad and P. Kumar
Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.
21 May 2019
11 November 2019
03 February 2020
01 March 2020