A REVIEW ON ELECTROPHORESIS, CAPILLARY ELECTROPHORESIS AND HYPHENATIONSAbstract
Electrophoresis is an effective analytical tool for separation, as it does not affect the molecular structure, and it is also highly sensitive to small differences in molecular charge and size of the analytes. Capillary electro-phoresis is a separation technique where the ions are separated based on their electrophoretic mobility with an applied voltage. So far, the research field of capillary electrophoresis remains very active, as exhibited by a steady and significant flow of scientific reports on theory, separation modes, new instrumentation, and applications of CE techniques in various areas. Capillary electrophoresis is the most predominately used because it gives faster results and it provides a high-resolution separation. It is one of the useful techniques because there is a large range of detection methods available. This paper is devoted to providing a brief explanation of types of electrophoresis; capillary electrophoresis, and CE-based separation modes with some advantages and disadvantages along with applications. This paper also includes some of the hyphenation techniques based on capillary electrophoresis (CE-MS, CE-ICP-MS, CE-ESI-MS, CE-MALDI-MS, and CE-NMR).
S. Gummadi * and V. N. Kandula
Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India.
18 February 2020
08 May 2020
24 November 2020
01 December 2020