A REVIEW ON OSMOTIC PUMP DRUG DELIVERY SYSTEMAbstract
Drug release from novel drug delivery systems are desired to be controlled at target site in effective concentration for required therapeutic action with predictable plasma concentrations, unlike conventional ones, thereby reducing the dose, dosage frequency, toxic adverse effects, reduction of blood level fluctuations, improved patient compliance and minimization of drug accumulation. As this can be achieved by the phenomenon called osmosis, osmotic pump drug delivery systems are proved as one of the most promising oral drug delivery systems in the recent times. They are tablets coated with semipermeable membrane which causes pores in water and desired drug release occurs. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. In the present review, a summary of the collected information on the osmotic drug delivery system has been discussed in detail.
M. Mathur * and R. Mishra
Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmadabad, Gujarat, India
29 July, 2015
06 October, 2015
13 November, 2015
01 February, 2016