A REVIEW ON RECENT DEVELOPMENT OF PYRAZOLINE AS A PHARMOCOLOGICALLY ACTIVE MOLECULEAbstract
Pyrazoline, among the various 5-membered heterocyclic compound derivatives has drawn attention towards it because of its various pharmacologically activities associated with it. Pyrazolines are a five membered heterocyclic having two adjacent nitrogen atoms within the ring with only one endocyclic double bond and is basic in nature. A lot of research work has been done on synthesis and biological activities of various pyrazoline derivatives over the years. Pyrazolines derivatives display tremendous biological activities such as antimicrobial, anti-inflammatory, analgesic, antipyretic, antidepressant, antitubercular, antiamoebic, anthelmintic, anticonvulsant, antihypertensive, antidiabetic, antitumor, anti-HIV, local anaesthetic, antioxidant, insecticidal, tranquilizing and receptor selective biological activity. The history of pyrazoline shows that it attracted many chemists to explore pyrazoline as a biologically active molecule. The study of biological evaluation of pyrazoline derivatives has been an interesting field of pharmaceutical chemistry. This review article focuses on the pharmacological profile of pyrazoline with various activities and examples in form of figures.
Rubina Bhutani *, Dharam Pal Pathak , Asif Husain , Garima Kapoor and Ravi Kant
Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India
24 March, 2015
13 May, 2015
23 June, 2015
01 October, 2015