A REVIEW: ROLE OF DOXORUBICIN IN TREATMENT OF CANCERAbstract
Cancer is a very complex genetic disorder that is mainly caused by carcinogens. Carcinogens can be present in the air, water, food, chemicals, and sunlight that are exposed to the people. In the case of leukemia, the body produces large numbers of abnormal white blood cells. In the study of blood cancer that is leukemia, blood disorders through visual inspection of microscopic images of blood cells is an important diagnostic tool. From the identification of blood disorders, it can lead to the classification of certain diseases related to blood. Doxorubicin drug most useful for cancer treatment such as Breast cancer, ovarian cancer, Lung cancer, Neuroblastoma cancer, Leukemia, etc. In breast cancer, the efficacy of drug treatment will thus depend on the histology of the tumor tissue. In ovarian cancer, the doxorubicin metabolites accumulated in the ascites and cleared more slowly from the peritoneal compartment than from the serum. Accumulation in the peritoneal cavity with prolonged half-life should be considered when administering medication in patients with ascites. In lungs cancer, the aggregate results of the present series of studies demonstrate that RLIP76 is the predominant doxorubicin transporter in the lung cancer cell. That its transport and ATPase activity is greater in NSCLC than SCLC and that its inhibition by anti-RLIP76 IgG augments doxorubicin cytotoxicity though it’s increased accumulation in cells. In neurotumor cells the doxorubicin-induced apoptosis is ceramide-mediated and whether p53 up-regulation is necessary for the apoptotic response.
A. Kumar *, B. Gautam, C. Dubey and P. K. Tripathi
Department of Pharmacy, Rameshwarm Institute of Technology and Management, Lucknow, Uttar Pradesh, India.
28 March 2014
15 June 2014
01 July 2014
01 October 2014