A STUDY OF AQUEOUS FILM COATING ON MICROCRYSTALLINE HYDROXY APATITE COMPLEX TABLETSAbstract
Water soluble polymers such as Hydroxy Propyl Methyl Cellulose (HPMC), Poly Vinyl Pyrrolidone (PVP), Carboxy Methyl Cellulose – Sodium (CMC – Na), and Methyl Cellulose as well as in combination of varying proportions are used in this study for the protective coating of Microcrystalline Hydroxy Apatite Complex (MCHC). The objective of this study was to investigate the effect of aqueous film coating on MCHC tablets evaluated by comparison with plain MCHC tablets and non-aqueous coated tablets. The parameters evaluated were the film smoothness, shininess, coating uniformity, percentage weight increase, hardness, disintegration time, dissolution study, moisture adsorption, stability and toxicity. An aqueous film coating solution in different combinations was applied on the tablets using a laboratory coating pan at 60oC, in the atmospheric pressure. By using the same method non aqueous film coating solution was applied on the MCHC tablets and the tablet bed temperature maintained at 40oC. The study has shown that HPMC and PVP combination in the proportion of 5% and 1% as coating material gave promising results in the evaluation of tablets.
N. Narayanan*, S. Daisy Chella Kumari , N. Deattu and V. Revathi
Director, Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India
20 August, 2012
29 October, 2012
25 November, 2012
01 December, 2012