A STUDY OF IN-VITRO WOUND HEALING ACTIVITY IN THE METHANOL EXTRACT OF PROTOREASTER LINCKII
AbstractA wound is an injury of living tissue or a break in the epithelial integrity of the upper layer of skin. This may lead to disturbance of skin anatomical structure and functions. Nowadays, wound healing is a challenging clinical problem. So, effective wound management is required. Different in-vitro, in-vivo and ex-vivo models have been developed to evaluate wound healing activity. The present study aims to evaluate the in-vitro wound healing potential of methanol extract of starfish Protoreaster linckii on the Human L-32 Cell line through scratch assay. The wound-healing properties of the Protoreaster linckii extract at different concentrations (25µg/ml, 50µg/ml and 100µg/ml) were assessed. The wound closure and migration of cells were directly related to the concentrations of the extract. The extract concentration increased from 25µg/ml to 100µg/ml and the percentage of wound healing (40% – 98%) also increased. The results showed that the methanol extract of P. linckii has potential wound-healing activity and it can serve as an alternative therapy against synthetic drugs for wound healing.
Article Information
32
3498-3501
6409 KB
296
English
IJPSR
A. Maria Selva Francis * and Jemma Hermelin Jesy Diaz
Department of Zoology, St. Mary’s College, Thoothukudi, Manonmaniam Sundaranar University, Abhishekapatti, Tirunelveli, Tamil Nadu, India.
mariaselvafrancis1995@gmail.com
28 October 2022
02 January 2023
01 May 2022
10.13040/IJPSR.0975-8232.14(7).3498-01
01 July 2023
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