A STUDY ON DIHYDROFOLATE REDUCTASE AND ITS INHIBITORS: A REVIEWAbstract
Dihydrofolate reductase (DHFR) was discovered in the late 1950s by investigators searching for folate-dependent enzymes involved in 1-carbon metabolism, with its already known application as anti-cancer and as antibiotics. This study focuses on structure of Dihydrofolate, its interaction with specific amino acids, mechanism of DHFR catalysis. The reason of study was to focus on compounds which can inhibit DHFR and has applications as antifungal agents, antimalarial agents, ant tuberculosis agents, for Leishmaniasis and Trypanosomiasis treatment. Also, to find out the reason of resistance to antifolates and ways to overcome them, recent drugs under each class of agents and drugs under clinical trials.
A.S. Rao* and S. R. Tapale
AISSMS College of Pharmacy, Kennedy Road, Near RTO Office, Pune- 411 041, Maharashtra, India
04 March, 2013
01 May, 2013
17 June, 2013
01 July, 2013