A STUDY ON EFFECT OF THERMAL SINTERING ON GASTRIC FLOATING TABLETSAbstract
The purpose of this study was to develop a gastroretentive controlled release drug delivery system using sintering for enhanced oral bioavailability using carnauba wax polymer. Formulations (CC1-CC3) were prepared by wet granulation method and then exposed to sintering temperature at different time intervals. The optimized formula showed zero-order drug release kinetics for the period of 12 h. The results revealed that sintering temperature and time of exposure significantly affected the in-vitro drug release and floating character. FTIR Spectra showed no noticeable incompatibility between drug and polymers in both physical mixtures and in the formulation.
M. G. Ramya * and K. B. C. Sekhar
Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.
30 January 2020
10 March 2020
19 March 2020
01 April 2020