A STUDY ON FORMULATION AND DEVELOPMENT OF GASTRO-RETENTIVE FLOATING DRUG DELIVERY SYSTEM OF CURCUMIN FOR STOMACH TUMORS AND ULCER

Purpose: To prepare and evaluate floating tablet of curcumin for prolonged gastric residence time and increased drug bioavailability for the treatment of gastric problem. Methods: Floating tablet were prepared by wet granulation method using different ratios of Curcumin, Psyllium husk, HPMC K 15 M, HPMC K 100 M and Mangifera indica gum. The respective powders were blended thoroughly and a dump mass was prepared by adding the granulating agent. Dump mass was passed through sieve number 10 and dried in hot air oven at 50 ⁰C for 30 mins. After drying, granules were further passed through sieve number 22 to attain the uniformity in granules. Finally, optional additives like magnesium stearate and talc were added and finely blended for preparation of floating tablet. Result: Floating drug delivery tablets were being formulated and the present study focused on the formulation of FDDS by using different polymes like phyllium husk, HPMC K 100 and HPMC K15 and to evaluate its efficacy in reducing ulcers caused by H.pylori. The Floating drug delivery tablets were characterized for their weight variation, hardness, friability, drug content determination, disintegration, in-vitro dissolution studies, IR, floating lag time, swelling studies and erosion studies. Conclusion: The developed curcumin floating tablet system is a promising floating drug delivery system for oral sustained administration of curcumin.