A STUDY ON HEPATOPROTECTIVE ACTIVITY OF ETHANOL EXTRACT OF ZANTHOXYLUM ARMATUM DC (MUKTHRUBI) LEAVES IN EXPERIMENTAL ANIMALAbstract
Zanthoxylum armatum is administered as a hepatoprotective agent during indigestion and hepatic related diseases by traditional healers. So, the aim of this study was to investigate the hepatoprotective activity of ethanol extract of Z. armatum (ZAE) in Paracetamol induced hepatotoxicity in albino rats in comparison with the activities of the known and potent hepatoprotective standard drug Silymarin. Treatment with ZAE showed a significant (p< 0.001 – 0.05) decrease in SGOT, SGPT, direct bilirubin and total bilirubin when compared to paracetamol induced control group while the serum level of protein particularly albumin is elevated with the treatment of ZAE in comparison to normal rats and Silymarin treated paracetamol induced group. This means that treatment with ZAE significantly reversed the hepatic changes produced by paracetamol treatment in rats. The possible mechanism of action may be explored by studying the antioxidant effect of the ZAE. The present study demonstrates that the ethanol extract of Z. armatum significantly protects the liver against paracetamol induced hepatic toxicity in healthy albino rats.
J. Oinam, I. Raleng, P. Meitankeishangbam, B. R. Kumari, S. Laishram*
Department of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences, Imphal, Manipur, India.
04 January, 2017
06 March, 2017
22 March, 2017
01 July, 2017