A STUDY ON SERUM TOTAL BILIRUBIN AND URIC ACID IN NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUSAbstract
Background: Serum total bilirubin (SBT) and serum uric acid (SUA) have anti-oxidant properties. SBT and SUA may be potential biomarkers for type 2 diabetes mellitus (T2DM) and its complications. Aim: It is aimed to evaluate the level of STB and SUA in T2DM. Materials and Methods: In this case-control study, a total of 124 subjects (62 T2DM cases and 62 age and gender-matched controls) were recruited between the age group of 30-55 years. Fasting blood sugar (FBS), STB, SUA, Malondialdehyde (MDA), and Superoxide dismutase (SOD) were estimated. All the data were tested at a 5% level of significance. Results: The mean level of SUA was significantly higher in cases than controls (P=0.009). However, the mean level of STB was not found statistically significant in cases than controls (P=0.08). The mean level of MDA was found significantly elevated in cases than controls (P<0.001). In addition, the mean of SOD activity was found significantly low in cases than controls (P<0.001). A significant negative correlation was found between age and SOD activity (r= -0.327, P<0.05). However, a significant positive correlation was found between STB and MDA (r= 0.398, P<0.05). In addition, A significant negative correlation was found between MDA and SOD activity (r = -0.704, P<0.01). However, a positive correlation was found between STB and SUA, but not statistically significant (r= 0.071, P>0.05). Conclusion: Results showed that the SUA and MDA levels are elevated, and STB level and SOD activity are depleted in T2DM cases. These findings may give further insight into the pathogenesis and management of T2DM.
M. Mishra, D. Tiwari *, M.M. Khan
Department of Biochemistry, Integral Institute of Medical Sciences and Research (IIMS&R), Integral University, Lucknow, Uttar Pradesh, India.
20 May 2020
23 October 2020
27 October 2020
01 November 2020