A STUDY ON SERUM UREA AND CREATININE IN DIAGNOSED CASES OF SUBCLINICAL HYPOTHYROIDISMAbstract
Hypothyroidism is a progressive disorder characterized by varying degrees of thyroid failure, metabolic consequences, and hemodynamic changes that decrease renal plasma flow and glomerular filtration rate, increasing serum creatinine level. Therefore, the present study aimed to evaluate and analyse the level of serum urea, creatinine and thyroid function tests in cases of subclinical hypothyroidism and apparently healthy controls and determine whether thyroid dysfunction has detrimental effects on serum creatinine and urea levels in subclinical hypothyroidism cases. Both thyroid function tests (TSH, T3, and T4), serum urea, and creatinine were analyzed in 45 cases with subclinical hypothyroidism and 45 healthy subjects. Patients with subclinical hypothyroidism had a statistically significant rise in creatinine levels compared to controls. In contrast, there was no significant difference in serum urea levels between patients and controls. There was likewise a positive correlation between creatinine and urea in patients with subclinical hypothyroidism. The study results indicate that renal function should be regularly monitored in patients with subclinical hypothyroidism.
Ajit Kumar Yadav, Priyanka Thapa Manger * and Richa Awasthi
Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, Uttar Pradesh, India.
01 April 2022
12 May 2022
21 May 2022
01 June 2022