A STUDY ON THE HEPATOPROTECTIVE EFFECTS OF ETHYL ACETATE EXTRACT OF SPILANTHES ACMELLA IN PARACETAMOL-INDUCED HEPATOTOXICITY IN EXPERIMENTAL ANIMALSAbstract
Spilanthes acmella plant has been used for various purposes in traditional medicine since time immemorial. The present study aimed to determine the hepatoprotective activity of ethyl acetate extract of Spilanthes acmella in Paracetamol-induced hepatotoxicity in experimental animals. The leaves and flowers of this plant were used for this study, and the experiment was carried out in albino rats. The ethyl acetate extract at 100mg/kg and 200mg/kg body weight was evaluated by inducing hepatotoxicity with paracetamol at a dose of 2g/kg body weight and using Silymarin 100mg/kg as the standard reference drug. The hepatoprotective activity was monitored biochemically by estimating serum levels of AST, ALT, ALP, Total Protein, and Total and direct bilirubin. The extract exhibited significant (p<0.05) hepatoprotection in a dose-dependent manner in paracetamol-intoxicated albino rats. The hepatoprotective effects of the extract were comparable to the Standard drug, Silymarin, therefore suggesting further in-depth studies.
P. Chakraborti *, Z. Sailo and V. Valte
Department of Pharmacology *, Jawaharlal Nehru Institute of Medical Sciences, Imphal, Manipur, India.
24 August 2022
12 October 2022
14 November 2022
01 May 2023