A STUDY ON THE ROLE OF DIETARY AGENT MOMORDICA CHARANTIA L ON PROTEIN GLYCATION
AbstractProtein glycation is a spontaneous post translational modification of proteins by excess sugars causing formation of advanced glycation end products (AGEs) in diabetic individuals and responsible for diabetes complications. A wide variety of anti-glycating agents have been reported & recently there has been interest in natural products with anti-glycation properties. Momordica charantia L (M. Charantia L) has been used historically for medicinal purposes particularly for treatment of diabetes & cancers. M. Charantia L Extract contains potent antioxidant activity and it can be a useful anti-glycating agent. Material & methods: Human serum albumin was used for in vitro glycation. Various concentrations of extract of M. Charantia L were analyzed. Results: Co-incubation of the M. Charantia L. extract with HSA-fructose mixture intensify the fructose mediated glycation of HSA as indicated by increases fluorescence intensity in tryptophan fluorescence &AGE related fluorescence studies. Conclusion: M. Charantia L. seems to aggravate sugar mediated glycation of the protein and need further studies to pinpoint specific bioactive compounds responsible for the observed activities
Article Information
44
2168-73
482
1261
English
IJPSR
Gini Garima, Neeraj Kumar Agrawal *, Shagufta Moin and Pankaj Kumar Gupta
Department of Pharmacology, Himalayan Institute of Medical Science, SRH University, Dehradun, Uttarakhand, India.
drneer80@yahoo.com
11 December, 2015
18 January, 2016
13 February, 2016
10.13040/IJPSR.0975-8232.7(5).2168-73
01 May, 2016
Download