A SYSTEMATIC REVIEW ON DEVELOPMENT AND EVALUATION OF CONTROLLED RELEASE AND FAST DISSOLVING FORMULATIONS FOR ANTI-DIABETIC DRUGS OVER PAST DECADEAbstract
Diabetes mellitus is the heterogeneous metabolic disorder caused by the high blood sugar level. Untreated high blood sugar can damage kidneys, eyes, nerves and other organs. Type 1 diabetes mellitus disorder is caused by the lack of insulin hormone while type 2 diabetes mellitus is a disorder of insulin resistance by β cells of the pancreas. For the management of type 2 diabetes mellitus different drugs are available as single or combination forms like Pioglitazone, Repaglinide, Metformin, Voglibose, Glipizide. Several research activities were carried out for its development, formulation and evaluation by the development of controlled-release and fast-dissolving formulations. The extensive literature review revealed information related to the formulation of sustain/fast release dosage form for the antidiabetic drugs. Newer techniques were used by the researcher for the formulation of dosage forms as solvent diffusion-evaporation technique, Reverse phase evaporation technique, emulsion solvent evaporation technique and Hot melt extrusion granulation technique. The review represents the types of formulation, methods used, excipients used and evaluation parameters of developed dosage forms and their correlation with therapeutic success.
M. K. Munde *, N. S. Kulkarni and D. B. Sen
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
18 October 2019
19 June 2020
25 August 2020
01 October 2020