A SYSTEMATIC REVIEW ON DRUG REPOSITIONING: A NEW METHODOLOGY TO DRUG DISCOVERYAbstract
At a time where we understand that new drug discovery and development involves significant cost, expensive products and is the slow-paced process, an innovative idea called ‘Drug Repositioning’, which basically means repurposing of old drugs to treat diseases including both common and rare are being increasingly attractive as it provides drug development in a sustainable cost, time efficiently and the product value is also low, making it less risky for pharmaceutical investment. A drug initially marketed as an anti-anginal drug repurposed for erectile dysfunction (Sildenafil/ Viagra) is an important example of landmark evidence in history. Similarly, over the years, several drugs have been successfully repurposed into other drug uses to treat various diseases. In this systematic review article, we have focused on the wholesome idea and methodologies of drug repurposing and its approaches, methods, challenges and strategic advantages over traditional drug discovery in the present scenario.
Abhilash Poudyal, Barsha Subba and Sonam Bhutia *
Government Pharmacy College Sajong, Government of Sikkim, Sikkim University, Sajong , Sikkim, India.
12 September 2021
25 October 2021
12 November 2021
01 June 2022