ABERRANT EXPRESSION OF WNT/BETA-CATENIN SIGNALING PATHWAY AND IN -VITRO CYTOTOXIC ACTIVITY OF TRADESCANTIA SPATHACEA MEDICINAL PLANT USED TO TREAT HUMAN BREAST ADENOCARCINOMA (MCF-7 CELL LINES)

Cancer plays crucial role in human life and critical disease to cure. Signaling pathways involved in stem cells development process. Especially, Wnt/β-catenin signaling pathway plays important role in stem cells self-renewal, differentiation and proliferation. Despite, over expression and mutation of Wnt/β-catenin signaling pathway induced variety of cancer development. Anticancer activities of several natural and synthetic agents were used to treat many cancer types. Many synthetic agents were used to cure various cancer but they have their toxicity. So, plant derived chemotherapeutic agents are going to investigate against cancer without side effect. In this paper we evaluate anticancer properties of Tradescantia spathacea medicinal plant and aberrant expression of β-catenin protein in human breast adenocarcinoma cell line (MCF-7). The plant leaves were collected, shade dried and extracted with hydroalcohol using soxhlet. Cytotoxic activities were assayed with MTT colorimetric procedure against MCF-7 cell lines. From the result, plant leaves extracts showed nearly 50 % MCF-7 cell line inhibition at 229.7µg/ml tested dose.