ACCELERATING NITRENDIPINE DELIVERY: NANOSUSPENSION FAST-DISSOLVING FILM FOR ORAL TRANSDERMAL USE

The present research work is aimed to formulate and evaluate Nitrendipine nanosuspension (NTD-NS) and nanosuspension loaded oral fast dissolving film (NS-OFDF) to improve its low solubility and bioavailability. Wet media milling technique was employed to prepare NTD-NS, which was optimized and evaluated for different parameters. Poloxamer 188, Poloxamer 407, HPC, HPMC E5, HPMC E15, HPMC E50, HPMC K4M, PVP K30 were used for preparing various nanosuspension formulations. HPMC E15 and SLS were used to formulate optimized nanosuspension. NTD-OFDF was prepared using the optimized nanosuspension by solvent casting method. PEG 400 is added during film formation as plasticizers and HPMC is added as film former polymer. The NTD-OFDF were prepared, optimized and evaluated for different parameters. Optimized NTD-NS depicted particle size of 455.2 nm with polydispersity index (PDI) of 24.9% and zeta potential of -24.2 mV. Optimized NTD-OFDF exhibited surface pH of 7.12±0.0251, folding endurance of321±4, thickness of 0.171±0.003, disintegration time of 28.133±0.493 sec which was in the standard limits. The drug release from NTD-NS loaded OFDFs increased significantly, reaching a maximum of 80.84±0.445 % in pH 7.4 buffer, the release data was fitted into first order model yielding the highest correlation coefficient (R²) (R²=0.925).