ACECLOFENAC ENCAPSULATED ETHANOLIC NANO-VESICLES FOR EFFECTIVE TREATMENT OF OSTEOARTHRITISAbstract
In the present study, ethanolic nanovesicles of Aceclofenac developed for the site specific delivery to joints for effective treatment of osteoarthritis. Ethanolic nano-vesicles were prepared by solvent dispersion method. Vesicles were characterized for vesicular size, surface morphology, size and size distribution, zeta potential, entrapment efficiency. Formulations were also evaluated for drug-vesicle (excipients) interaction, in vitro permeation, in vitro deposition. The TEM showed dark vesicular structures by which it is possible to notice the outer most bilayer. In the ethanol concentration range of 20-40%, the size of the vesicles increased with decreasing ethanol concentration, with the largest vesicles in preparations containing 20% ethanol (809.34±2.329 nm) and the smallest in preparations containing 40% ethanol (627±3.684 nm). Zeta potential of formulations shows negative value, which indicates that, the higher concentration of ethanol make the negative charge on vesicles surface. The entrapment was found to increase with increase in ethanol concentration, however percent entrapment decreased when ethanol concentration exceeded 40%. The FTIR spectra reveled no considerable change in IR peaks of Aceclofenac loaded ethanolic vesicles when compared to pure drugs there by indicating absence of any interaction.
Arvinder Kaur*, Sunil K. Jain and Ravi S. Pandey
Pharmaceutics Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495 009, Chhattisgarh, India
03 April, 2012
02 May, 2012
19 July, 2012
01 August, 2012