ADVANCED GLYCATION END PRODUCTS IN PROGRESSIVE COURSE OF DIABETIC NEPHROPATHY: EXPLORING INTERACTIVE ASSOCIATIONS

Diabetic nephropathy is a major complication of diabetes and the most common cause of end stage renal damage (E.S.R.D). Diabetic nephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialized nations. Hyperglycemias, hyperlipidaemia and hypertension are considered to be the major risk factors implicated in the progression of nephropathy. Possible mediators of untoward effects of hyperglycemias include advanced placation end products (AGEs) known to accumulate in diabetic subjects. However, mechanisms underlying the pathogenesis of diabetic nephropathy are not completely understood. AGEs have been recently reported to play an important role in the pathogenesis of diabetic complications, particularly in the progression nephropathy. At present, no promising therapy is available to treat patients with diabetic nephroapthy due to lack of understanding of mechanism involved in the pathogenesis of nephropathy. There have been wide-ranging reports underline the involvement of AGEs in progression of the diabetic nephropathy, but the exact mechanism is not known clear yet, Therefore in these review are trying to explore the interactive association of AGEs in diabetic nephropathy.