Akt: A NEW APPROACH FOR CANCER TREATMENTAbstract
Direct genetic alterations leading to deregulated PI3K/Akt signaling are common in a significant fraction of human malignancies. Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. Nuclear Akt1 expression and Akt activation are common in cancer invasion. However, the mechanisms for this association and its causal role in invasion are uncertain. It is a key downstream eﬀector of phosphoinositide 3’-kinase (PI3K) and directly modulates a wide range of pro-apoptotic and metabolism regulating proteins. Inhibition of Akt is a signiﬁcant therapeutic goal due to the prevalence of activating mutations in the PI3K/Akt pathway.
Devendra Singh Thakur*, Peeyush Kumar, Pramod Kumar and Champa Lal
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (CG), India
24 April, 2010
18 June, 2010
27 July, 2010
15 August, 2010