ALLOPOLYHERBAL GEL FORMULATION AGAINST MICROORGANISM: IN-VITRO STUDIESAbstract
The cases of skin infections are increasing daily, and the conventional treatment loses its strength in treating those skin infections because of resistance of the microorganisms against the medications, including antibacterial as well as antifungal with the topical and oral administration, or both. The advancement of the treatment of treating skin infections by the combination with the synthetic drug (allopathic medicine) with the polyherbal formulation is known as Allopolyherbal formulation, which gives a wonderful result in the treatment of skin infections due to microorganisms (bacteria & fungus) by lowering the side effects and increasing the pharmacological activity of the synthetic drug (allopathic medicine) with the synergistic therapy in targeting the microbes and also shows the better patient compliance with the reliable therapeutic effects. In this research work, the allopolyherbal formulation contains the polyherbal formulation, which includes A. indica (Neem), O. tenuiflorum (Shyamatulsi), P. emblica (Amla), and A. barbadensis (Aloe) which have the potency enriched with antimicrobial activity and the allopathic drug, the antibacterial (chloramphenicol) and antifungal (terconazole) are used to treat many of the skin infections caused by S. aureus, P. aeruginosa, C. albicans, and A. niger. The overall resulted formulation of allopolyherbal gel as antibacterial (F4) and antifungal (F4) with PHF (B) shows better eradication rate as compared to all formulation and also the further evaluation such as physicochemical as well as in-vitro studies with stability was performed for particular formulation.
Laxmi Srivastava, J. N. Mishra, D. K. Vishwakarma * and Chitranshu Pandey
Kailash Institute of Pharmacy & Management, Gida, Gorakhpur, Uttar Pradesh, India.
09 June 2022
25 July 2022
04 August 2022
01 February 2023