AMELIORATING EFFECT OF TURMERIC ON KIDNEY FUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Background: Diabetes mellitus is one of the most common metabolic disturbances associated with carbohydrates, lipids, proteins, and relative or absolute insulin depletion. Various long-term complications of diabetes develop due to chronic hyperglycemia and insulin resistance. Chronic kidney disease (CKD) and diabetes mellitus (DM) are major public health problems worldwide. Turmeric is one of the medicinal herbs studied for antioxidant, antibacterial, and antifungal effects. Curcumin has been established to be defensive against nephropathy. Objective: The purpose of this study was to assess turmeric’s effect on different kidney function parameters in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: Two hundred patients with T2DM were selected in randomized control trial, of which 100 subjects were enrolled in the study group, were given 500 mg of raw turmeric powder in capsule form daily along with their antidiabetic drug medication (Metformin) for 3 months period while 100 subjects on medication of antidiabetic drug (Metformin) were selected as a control group. Serum levels of urea, creatinine, total protein, albumin, and globulin were measured at baseline and after 3 months intervention period. Results: Showed a significant reduction in serum creatinine and significant improvement in total proteins and albumins in the study group by the end of 3 months of turmeric supplementation. Conclusion: Supplementation of turmeric leads to improved plasma proteins and decreased serum urea and creatinine levels in T2DM patients and could be useful in the improvement of kidney function in T2DM.