AMELIORATION OF DEXTRAN SULPHATE SODIUM INDUCED ULCERATIVE COLITIS IN MICE BY STEM BARK EXTRACT OF TERMINALIA TOMENTOSAAbstract
A plethora of herbs have been tested for their activity against ulcerative colitis, a debilitating disease in the group of IBDs. However, a promising adjuvant to conventional therapy remains still at large. Ellagic acid, a polyphenol widely available in berries have shown efficacy against ulcerative colitis in preclinical models. Owing to its high content of ellagic acid and its analogs, the stem bark of Terminalia tomentosa was chosen for our study. Effect of Terminalia tomentosa hydroalcoholic extract and its ellagic acid-rich fraction were tested for their anti-colitic potential in DSS (5%) induced ulcerative colitis in mice. The evaluation was carried out for assessing the severity of disease at macroscopic biochemical and histopathological level. Myeloperoxidase and superoxide anions, an inflammatory and an oxidative marker respectively were also evaluated in all the groups. Amongst all, the highest significance was observed in the group treated with an ellagic acid-rich fraction (200 mg/kg). The ameliorative effect has been attributed to the high antioxidant potential of the fraction.
A. Das *, S. Patil, S. K. Mukhopadhyay and A. G. Patil
Department of Pharmacology, Gupta College of Technological Sciences, Asansol, Burdwan (W), West Bengal, India.
02 May 2019
25 August 2019
01 September 2019
01 February 2020