AMELIORATIVE EFFECT OF CURCUMIN ON PROFENOFOS INDUCED OXIDATIVE DAMAGE OF RENAL TISSUE IN MICE

The aim of the present study is to evaluate the ameliorative effect of curcumin against profenofos induced oxidative damage of renal tissue in mice. Animals were divided into four different groups namely Group-I (control mice; NC), Group-II (NC gavaged 100µl ethanol for 30 days; EC), Group-III (NC gavaged 25mg/kg b.w profenofos for alternate 30 days; PC) and Group-IV (PC treated with 120mg/kg b.w of curcumin daily till next 30 days; CurTPE). Electron micrographs of kidney and level of lipid peroxidase (LPO) were estimated to investigate the therapeutic potential against profenofos treated subjects. Histological analyses of PC showed hemorrhages of blood capillary, edema, necrosis and glomeruli shrinkage but CurTPE showed significant improvement, as compared to PC. Electron microscopic studies also revealed partly destruction of nucleus, mitochondrial membrane, cristae and formation of large vacuoles in cytoplasm but CurTPE showed recovery when compared to PC. It was observed that the damaging effects of profenofos on nucleus, mitochondrial membrane and cristae of renal tissues. It might be due to decrease in lipid concentration and increased LPO concentration. Free radicals were generated exponentially due to increased concentration of LPO and reactive oxygen species (ROS) production which in turn adversely affected on several biomolecules and interfered with different metabolic pathways