AN APPROACH FOR ENHANCEMENT OF DISSOLUTION RATE OF PIOGLITAZONE HCL BY SOLID DISPERSION TECHNIQUE USING PEG 6000Abstract
Pioglitazone hydrochloride is a novel antidiabetic drug in thiazolidinediones group and it improves insulin sensitivity in insulin resistant patients. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. The present study is an approach to enhance the dissolution rate of pioglitazone HCl by preparing solid dispersion (solvent evaporation method) using PEG 6000 as carrier in the ratios of 1:1, 1:2, 1:3 and 1:5 respectively. The drug carrier interaction study was carried out by Fourier Transform Infrared Spectroscopy (FTIR). The prepared solid dispersions were characterized for percentage yield, bulk density, tapped density, Carr’s Index, Hausner’s ratio, angle of repose, drug content, in vitro drug dissolution and stability study. The FTIR study suggesting no interaction between physical mixture of drug and carrier. The solvent evaporation was found to be efficient method to obtained good yield solid dispersions with good flow properties. The drug content was found in the ranges of 72.87±0.31 to 85.23±0.22 %. The solid dispersion of pioglitazone is releasing maximum amount of drug within 60 min where as pure drug is releasing 21.80±0.85 % only. Among all the solid dispersion formulations, formulation F3 of drug carrier ratio 1:3 was found to be best for releasing maximum drug (98.50±1.09 %) with good drug content. All pioglitazone solid dispersions were found to be stable in various storage temperatures. All data are found to be significant by applying one way ANOVA at 5 % level of significant (p<0.05).
Sruti Ranjan Mishra*, P. Ellaiah , Prabhat Kumar Jena , Bhabani Shankar Nayak and Gitanjali Mishra
Asst. Proffesor, Jeypore College of Pharmacy, Rondapalli, Jeypore- 764002, Koraput, Odisha, India
16 June, 2011
22 July, 2011
18 September, 2011
01 October, 2011