AN ASSOCIATIVE INVESTIGATION BETWEEN TSH AND SERUM LIPID CONCENTRATIONS IN THE POPULATION OF BHOPAL, INDIAAbstract
The association between TSH and serum lipids in people with no apparent thyroid dysfunction is less understood. We have investigated the association between normal thyroid function, defined as TSH within the reference range and serum lipids concentrations. Cross-sectional, population based study with 1785 individuals without known thyroid dysfunction. We calculated mean concentrations of total serum cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, HDL cholesterol and triglycerides across categories of TSH, using general linear models. Within the reference range of TSH, there was a linear and significant (P for trend <0.001) increase in total serum cholesterol, LDL cholesterol, non-HDL cholesterol and triglycerides, and linear decrease (P for trend <0.001) in HDL cholesterol with increasing TSH. Within the range of TSH that is considered clinically normal, we observed that increasing level of TSH was associated with less favorable lipid concentrations. The association with serum lipids was linear across the entire reference range of TSH.
Rakesh Kumar Patidar, Ranjeeta Raghuwanshi, Preeti Sharma, Vinod singh*
Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India
19 December, 2011
15 January, 2012
27 March, 2012
01 April, 2012