AN EFFECTIVE AND FACILE VOLTAMMETRIC STUDY OF ATRACURIUM BESILATE AT FUNCTIONALIZED MWCNTs MODIFIED GLASSY CARBON ELECTRODEAbstract
In the present study, a modified glassy carbon electrode by a conductive film containing, i.e., functionalized multi-walled carbon nanotubes (f-MWCNTs) was selected for the determination of atracurium besilate (in short ACB), an anesthetic drug by applying the cyclic voltammetry (CV) and differential pulse anodic adsorptive stripping voltammetry (DP-AASV) techniques. Herein, nanomaterials suspension is prepared and further examined by field emission scanning electron microscopy (FESEM) analytical technique. All the effective electrochemical parameters for the detection of ACB drugs were optimized, and the oxidation peak current (Ip) of the drug was used for monitoring. The obtained results confirmed that the oxidation peak current (Ip) increased linearly by increasing in the concentration range from 1.25×10-7 M to 7.75×10-4 M of ACB. The limit of quantification (LOQ) and limit of detection (LOD) are 52.6 ng/mL and 1.43 ng/mL achieved, respectively. The sensor (nanomaterials modified glassy carbon electrode) revealed extreme sensitivity/sensing towards atracurium besilate (ACB) pharmaceuticals in bulk samples.
Mahadeva Singh Jat, Varsha Jakhar and D. K. Sharma *
Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India.
11 January 2021
08 June 2021
13 June 2021
01 December 2021