AN EFFICIENT SYNTHESIS, CHARACTERIZATION AND BIOACTIVITY OF BENZIMIDA-ZOLE LINKED TRIAZOLES
AbstractA series of benzimidazole-linked triazoles hybrids (4a-4u) have been synthesized by simple cyclization, followed by amide coupling and click reaction starting from o-phenylene diamines as substrates with 4-formylbenzioc acid, propargylamine and followed by treatment with aryl azides. The structure of synthesized compounds (4a-4u) was confirmed by spectral techniques. The prepared compounds were screened by the agar well diffusion method against both Gram-positive bacteria (S. aureus, B. subtilis, M. luteus and B. megatherium) as well as Gram-negative bacteria (E. coli, K. pneumoniae, S. typhi and S. paratyphi). Analysis of antibacterial activity profile of synthesized compounds revealed that compounds (4a) and (4c) exhibited prominent activity against all tested Gram positive and Gram-negative microbes.
Article Information
28
234-240
636 KB
24
English
IJPSR
Asghar Jafar Khan and Abdul Rahim Abdul Sami *
Department of Chemistry, Milliya Arts, Scince & Mangement Science College, Beed, Maharashtra, India.
phychemmax@gmail.com
01 August 2024
04 September 2024
24 September 2024
10.13040/IJPSR.0975-8232.16(1).234-40
01 January 2025
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