AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECTS OF AEGLE MARMELOS AND IT’S COMPARISON WITH PIRACETAM ON LEARNING AND MEMORY IN WISTAR RATSAbstract
Present study was done to evaluate the memory enhancing effect of Aegle marmelos and its comparison with the present standard treatment Piracetam in Wistar rats. The learning and memory was assessed using the elevated plus maze. The findings of the present study indicate that, Aegle marmelos extract treated animals at a dose of 100 mg/kg p.o. as well as 200 mg/kg p.o. showed significant decrease in transfer latency from 6th day to 7th day (p<0.05), but the percentage reduction was more with higher dose. When compared to the control group, this reduction was statistically significant (p<0.05). These findings demonstrate the facilitatory effect of Aegle marmelos on learning and memory (nootropic activity). This may be attributed to the involvement of neurotransmitters like acetylcholine, serotonin, noradrenaline and dopamine, which play a vital role in the cognitive functions.
Himani , Shankar Pratap , R. C. Verma*, Sharad Leve , Amod Sachan and R.K. Dixit
Lecturer, Department of Pharmacology, R.I.M.S, Safai, Etawah, Uttar Pradesh, India
15 December, 2012
25 February, 2013
23 March, 2013
01 April, 2013