AN IN-VITRO STUDY FOR MUCOADHESION AND CONTROL RELEASE PROPERTIES OF GUAR GUM AND CHITOSAN IN ITRACONAZOLE MUCOADHESIVE TABLETSAbstract
This study describes the effect of Guar gum and chitosan on formulation of mucoadhesive drug delivery system of itraconazole. Mucoadhesive strength, Drug content, Hardness, Friability, Weight variation, Moisture content and accelerated stability studies were performed to study the effect of polymers on prepared mucoadhesive tablets. Results of the present study clarified the potential of guar gum and chitosan in mucoadhesion and control release of itraconazole tablets. Both polymers i.e. Chitosan and guar gum were helpful for controlling the drug release in better way when used in proper combinations. When result of mucoadhesion was checked guar gum gives more mucoadhesive strength to the prepared tablets as compared to chitosan. Accelerated stability studies were performed on prepared formulations, results indicates that the formulations were stable that mince excipients used in the formulations were stable and are not causing major changes in drug release pattern after a period of 6 months. From above mentioned work it can be concluded that combination of Chitosan and guar gum is better and effective approach to have controlled mucoadhesive drug delivery system of Itraconazole.
A. A. Shaikh*, Y. D. Pawar and S. T. Kumbhar
Department of Pharmaceutics, Indira College of Pharmacy, “Niramaya” 89/2-A, Tathawade, Pune-411033, Maharashtra, India
21 January, 2012
22 February, 2012
21 April, 2012
01 May, 2012