AN IN-VIVO STUDY TO EVALUATE THE ANTI-ULCER ACTIVITY OF NĀRIKELĀ LAVANA IN PYLORIC LIGATION INDUCED ULCER IN WISTAR ALBINO RATS

Lavana kalpanas are pharmaceutical preparation in which the ‘Lavana’ and the selected ‘auṣadhadravyā’ are igniting together in a closed sampuṭā to obtain the drug ash as medicinal product. Nārikelā lavana, one among the lavana kalpana mentioned in Bhaiṣajyaratnāvali 30^th chapter and in Rasa taraṇgiṇi14^th chapter. Nārikelā lavaṇa proved to have a high amount of electrolytes like calcium and potassium, which have antacid properties. Here the common ingredient in this Kalpana is lavana, which possesses madhura–lavanarasa & śītaviryā and having pittahara property which might be the reason for the extensive use of Lavaṇa Kalpanasin pittajanyavikaras. The higher alkalinity of Nārikelā lavaṇa may also play an important role in its mode of action. Materials and Methods: Nārikelā lavana was prepared as per the reference in Rasa taraṇgiṇi, and analytical parameters were tested. The experimental study was conducted in pyloric ligated Wistar albino rats. Then the data were analyzed statistically using One Way ANOVA followed by Dunnett’s multiple “t” test as a post hoc test. Results & Discussion: The analytical parameters like pH, LOD, Total ash, Acid insoluble ash, water-soluble ash etc. were tested, and the results were found to be within the permeable limits. The trial drug (Nārikelā lavana) shows significant results in total acidity, free acidity, and ulcer index by analyzing various parameters indicating the anti-ulcer activity. Conclusion: The obtained results clearly indicate Nārikelā lavana possesses anti-ulcer activity.