AN OUTLOOK OF DIVERGENT APPROACHES FOR PRODUCTION OF NANOPARTICULATE BASED DRUG DELIVERY SYSTEMAbstract
The complications as well as expense had been increased in marketing new chemical entities (NCEs) due to their poor solubility, high toxicity, high dosage, non-specific delivery, in-vivo degradation and short circulating half-lives. Nanoparticles possess immense prospective as an efficient drug delivery system. Nanoparticulate-based delivery systems have potential to significantly impact on pharmaceutical industry and can make a huge impact through drug targeting because it leads to reduction in toxicity and increased efficiency of chemical entity. Nanoparticulate drug delivery system has been extensively useful in the field of pharmaceutical, because they results in controlled and sustained release properties and can decrease the gap between drug discovery and drug delivery. This review aims to summarize various production methods, attributes, drug loading, drug release pattern and pharmaceutical applications of NPs. In this review, numerous potential methods employed for fabricating NPs such as emulsification solvent evaporation method, solvent diffusion method, salting out technique, coacervation/precipitation and polymerization has been illustrated through sequential diagrams.
Sukhbir Singh *, Yashpal Singla and Sandeep Arora
Chitkara College of Pharmacy, Chitkara University, Patiala, Punjab, India
11 October 2014
28 January, 2015
25 February, 2015
01 July, 2015