AN UPDATE OVERVIEW OF RECENT ADVANCES ON FORMULATION DEVELOPMENT FOR COLON TARGETINGAbstract
In targeted drug delivery systems, there is one of the most important drug delivery systems is colon targeting drug delivery system. This system is mainly used in the treatment of diseases like colonic cancer, ulcerative colitis, Crohn’s disease. For local treatment of various bowel diseases colon is highly desirable. For the systemic action of nonpeptide drugs i.e., cardiovascular and antiasthmatic agents and protein-peptide drugs such as insulin, calcitonin, colon targeting is apparently useful. There are various approaches that have been proposed for targeted colon delivery; they include the pH, pressure controlled, time-controlled, microflora, osmotic controlled, and multi-particulates and novel techniques. The carriers used in this system are microsphere, synthetic polymers, liposomes and nanoparticles, matrix tablets and compression coated tablets etc.
B. Kumari, P. K. Upadhyay, M. Kumar *, S. Narwal, A. Pandurangan and A. Malik
M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.
11 July 2019
05 November 2019
07 February 2020
01 April 2020