ANALGESIC ACTIVITY OF ETHANOL EXTRACT OF FERONIA LIMONIA (L.) SWINGLE LEAVESAbstract
The study aimed to access the analgesic effect of Feronia limonia (FL, leaves of Feronia limonia (L.) Swingle). The leaves of FL were extracted with 95% ethanol and the dried extract (FLE) was administered intragastically (i.g.) at 100, 200 and 400 mg/kg. Analgesic effect was evaluated in two experimental animal models. Pretreatment with single dose of FLE also produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. In addition, single dose of FLE at 2g/kg body weight produce no observable acute toxicity in mice within seven days. These results demonstrate that FLE possess analgesic effects and has no obvious acute toxicity.
Smita Khare* and Prabhat Khare
Sagar Institute of Research, Technology & Sciences- Pharmacy, Bhopal, Madhya Pradesh, India
11 October, 2010
12 November, 2010
17 January, 2011
01 February, 2011