ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF OCIMUM SANCTUM (LINN) IN LABORATORY ANIMALSAbstract
Ocimum sanctum (L.) is popularly used as herbal remedy for various ailments. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was aimed to investigate the analgesic and anti-inflammatory effects of the leaves of Ocimum sanctum in laboratory animals. The ethanol extract of the leaves of O. sanctum was used to investigate the acute effect on analgesia by Hot-plate test in mice and on inflammation in rats using carrageenan-induced rat paw edema model. The extract showed a significant (p<0.05) dose dependent increase in reaction time in mice in the hot-plate test at the doses of 250 and 500 mg/kg body weight. The extract also exhibited promising anti-inflammatory effect as demonstrated by statistically significant (p<0.05) inhibition of paw volume by 43.33% at the dose of 500 mg/kg body weight at the fourth hour of study. This study suggests that the ethanol extract of Ocimum sanctum have both analgesic and anti-inflammatory activity in a dose dependent manner which supported its use as an analgesic and anti-inflammatory drug in folk medicine. This plant may be a useful source of lead components in the treatment of pain and inflammation.
J. M. A. Hannan*, Biplab Kumar Das , Azim Uddin , Rajib Bhattacharjee Banibrata Das , Habib S. Chowdury and A. S. M. Mosaddek
Department of Pharmacology, K. K. College of Pharmacy, Chennai, Tamil Nadu, India
26 April, 2011
11 July, 2011
22 July, 2011
01 August, 2011